NIMG-02. PACS-INTEGRATED AUTO-SEGMENTATION WORKFLOW FOR BRAIN METASTASES USING NNU-NET. (14th November 2022)

• Record Type: Journal Article
• Authors: Jekel, Leon; Bousabarah, Khaled; Lin, MingDe; Merkaj, Sara; Kaur, Manpreet; Avesta, Arman; Aneja, Sanjay; Omuro, Antonio; Chiang, Veronica; Scheffler, Björn; Aboian, Mariam
• Is Part Of: Neuro-oncology. Volume 24(2022)Supplement 7
• Page Start: vii162
• Page End: vii162
• Publication Date: 2022-11-14
• Subjects: Brain Neoplasms -- Periodicals; Brain -- Tumors -- Periodicals; Brain -- Cancer -- Periodicals; Nervous system -- Cancer -- Periodicals; 616.99481
• DOI: 10.1093/neuonc/noac209.622
• Languages: English
• ISSNs: 1522-8517

Abstract

Abstract: PURPOSE: Monitoring metastatic disease to the brain is laborious and time-consuming, especially in the setting of multiple metastases and when performed manually. Response assessment in brain metastases based on maximal unidimensional diameter as per the RANO-BM guideline is commonly performed 1, however, accurate volumetric lesion estimates can be crucial for clinical decision-making 2 and enhance outcome prediction 3 . We propose a deep learning (DL)-based auto-segmentation approach with the potential for improvement of time-efficiency, reproducibility and robustness against inter-rater variability. Materials and METHODS: We retrospectively retrieved 259 patients with a total number of 916 lesions from our institutional database from 2014 - 2021. Patients with prior history of local radiation therapy or surgery were excluded. Manually generated trainee segmentations were revised and adjusted by a board-certified radiologist and served as ground truth for evaluation of segmentation accuracy. Model performance was tested via dice-similarity-coefficient (DSC). Volumetric measurements were then obtained within our PACS-integrated workflow on Visage 7 (Visage Imaging, Inc., San Diego, CA) at the click of one button. RESULTS: For model training and evaluation, a train-test split of 90:10 on patient-level was performed (n= 234:25 (Patients), n= 861:55 (Lesions). A DL-algorithm (nnUNet) was incrementally trained on 10 batches of 23 patients. The DSC of the U-Net gradually increased throughout the training process and heuristically reached a plateau of 0.85. The sensitivity of the algorithm was 83% with detection of 46 out of 55 lesions in the testing dataset. The lesions that were not detected by the algorithm were below 5 mm in size. The false positive rate was 8% (n=4/50). CONCLUSION: Our study demonstrates the feasibility of PACS-based integration of automatized segmentation workflows of brain metastases. An incremental-training approach is recommended to adapt DL algorithms to specific hospital settings.