Effects of Aerobic Exercise on Systemic Insulin Degludec Concentrations in People with Type 1 Diabetes. (January 2023)

• Record Type: Journal Article
• Authors: Herzig, David; Groessl, Michael; Álvarez-Martínez, Mario; Reverter-Branchat, Gemma; Nakas, Christos T; Kosinski, Christophe; Stettler, Christoph; Bally, Lia
• Is Part Of: Journal of diabetes science and technology. Volume 17:Number 1(2023)
• Page Start: 172
• Page End: 175
• Publication Date: 2023-01
• Subjects: exercise -- high-resolution mass spectrometry -- insulin degludec -- type 1 diabetes; Diabetes -- Periodicals; Medical technology -- Periodicals; Diabetes Mellitus -- Periodicals; 616.462005
• DOI: 10.1177/19322968211043915
• Languages: English
• ISSNs: 1932-2968

Abstract

Background: There is conflicting evidence on the effect of exercise on systemic insulin concentrations in adults with type 1 diabetes. Methods: This prospective single-arm study examined the effect of exercise on systemic insulin degludec (IDeg) concentrations. The study involved 15 male adults with type 1 diabetes (age 30.7 ± 8.0 years, HbA1c 6.9 ± 0.7%) on stable IDeg regimen. Blood samples were collected every 15 minutes at rest, during 60 minutes of cycling (66% VO2 max) and until 90 minutes after exercise termination. IDeg concentrations were quantified using high-resolution mass-spectrometry and analyzed applying generalized estimation equations. Results: Compared to baseline, systemic IDeg increased during exercise over time ( P < .001), with the highest concentrations observed toward the end of the 60-minute exercise (17.9% and 17.6% above baseline after 45 minutes and 60 minutes, respectively). IDeg levels remained elevated until the end of the experiment (14% above baseline at 90 minutes after exercise termination, P < .001). Conclusions: A single bout of aerobic exercise increases systemic IDeg exposure in adults on a stable basal IDeg regimen. This finding may have important implications for future hypoglycemia mitigation strategies around physical exercise in IDeg-treated patients.