Association between AXIN1 gene polymorphisms and epithelial ovarian cancer in Chinese population. (1st April 2019)

• Record Type: Journal Article
• Authors: Zhang, Yan; Wang, Yanyun; Huang, Xingming; Li, Qin; Li, Kai; You, Di; Song, Yaping; Su, Min; Zhou, Bin; Wang, Wei
• Is Part Of: Biomarkers in medicine. Volume 13:Number 6(2019)
• Page Start: 445
• Page End: 455
• Publication Date: 2019-04-01
• Subjects: AXIN1 gene -- epithelial ovarian cancer -- morphisms -- PCR-RFLP -- single nucleotide polymorphisms -- Wnt/β-catenin signaling pathway; Biochemical markers -- Periodicals; 610.28
• DOI: 10.2217/bmm-2018-0306
• Languages: English
• ISSNs: 1752-0363

Abstract

Aim: The study was aimed to explore the association between AXIN1 gene polymorphism and epithelial ovarian cancer (EOC) susceptibility as well as prognosis.Methods: A total of 165 EOC cases and 327 healthy controls were recruited to participate in this study. In total three tag SNPs in AXIN1 gene were genotyped using PCR-restriction fragment length polymorphism.Results: Significantly increased EOC risk was found associated with the A/C heterozygous genotype of rs12921862, the C allele and C/T genotype in the rs1805105 and the T/T genotype of rs370681. Meanwhile, Kaplan–Meier survival curves showed that patients with rs12921862 C/C genotype improved overall survival in the EOC group.Conclusion: Our results suggest that the AXIN1 gene may be related to susceptibility and overall survival in EOC.