Advanced glycation end products as biomarkers in systemic diseases: premises and perspectives of salivary advanced glycation end products. (10th April 2019)

• Record Type: Journal Article
• Authors: Băbţan, Anida M; Ilea, Aranka; Boşca, Bianca A; Crişan, Maria; Petrescu, Nausica B; Collino, Massimo; Sainz, Rosa M; Gerlach, Jared Q; Câmpian, Radu S
• Is Part Of: Biomarkers in medicine. Volume 13:Number 6(2019)
• Page Start: 479
• Page End: 495
• Publication Date: 2019-04-10
• Subjects: advanced glycation end products -- AGEs -- AGEs diagnosis and downregulation -- biomarkers -- biosensor -- chronic low-level inflammation -- diet-related disease -- metabolic syndrome -- metainflammation -- saliva; Biochemical markers -- Periodicals; 610.28
• DOI: 10.2217/bmm-2018-0448
• Languages: English
• ISSNs: 1752-0363

Abstract

Advanced glycation end products (AGEs) are glycated proteins associated with high dry temperature food processing, coloring and flavor modification of food products. Previous studies on diet-related disease support the role of the glycation products as biomarkers in local and general proinflammatory response. Exogenous and endogenous AGEs are involved in chronic low-level inflammation, which underlies the onset of metabolic syndrome influenced by food intake, there by demonstrating their implication in diet-related pathologies. Although studies have revealed a strong association between the accumulation of AGEs and the occurrence/worsening of metabolic diseases, their routine use for the diagnosis or monitoring of local and general disease has not yet been reported.