Antimicrobial and α-glucosidase inhibitory activities of chemical constituents from Gardenia aqualla (Rubiaceae). Issue 24 (17th December 2022)

• Record Type: Journal Article
• Authors: Nyemb, Jean Noël; Tchuenguem, Roland Tchuente; Venditti, Alessandro; Tchinda, Alembert Tiabou; Henoumont, Céline; Talla, Emmanuel; Laurent, Sophie; Iqbal, Jamshed
• Is Part Of: Natural product research. Volume 36:Issue 24(2022)
• Page Start: 6369
• Page End: 6374
• Publication Date: 2022-12-17
• Subjects: Gardenia aqualla -- Antimicrobial activity -- α-glucosidase -- triterpenoids -- pentapentacontene; Natural products -- Periodicals; Natural products -- Research -- Periodicals; Biological Factors -- Periodicals; Biological Products -- Periodicals; 547
• DOI: 10.1080/14786419.2022.2031187
• Languages: English
• ISSNs: 1478-6419

Abstract

Abstract: An aliphatic alkene namely pentapentacontene (4 ) was isolated for the first time from a natural source, Gardenia aqualla, along with fourteen other compounds including nonacosanol (1 ), tetratriacontanol (2 ), octatriacontanol (3 ), β -sitosterol (5 ) and stigmasterol (6 ), daucosanol (7 ), ursolic acid (8 ), uvaol (9 ), 3 β, 19 α, 23 β, 24 α -tetrahydroxyurs-12-en-28-oic acid (10 ), lupenone (11 ), oleanolic acid (12 ), vanillin (13 ), vanillic acid (14 ) and D-mannitol (15 ). α -glucosidase inhibitory assay revealed that MeOH and EtOAc extracts of leaves had the best activity with IC50 of 9.65 and 20.03 µg/ml respectively. All the tested compounds showed dose dependent inhibition of α -glucosidase and some of them were found to be comparable to acarbose. Compound 10 was the most potent with IC50 = 1.72 μM. It also showed the most interesting antibacterial activity, against the isolate strain of S. typhi and P. aeruginosa and also exhibited the most significant antifungal activities against all the tested yeasts. GRAPHICAL ABSTRACT: UF0001