Durability of antibodies post vaccination with two doses of inactivated BBIBP-CorV vaccine. (2nd December 2022)

• Record Type: Journal Article
• Authors: Mahmoud, Sally; Ganesan, Subhashini; Sharif-Askari, Narjes Saheb; Cantarutti, Flavia; Wilson, Hannah; Ogrodzki, Pauline; Halwani, Rabih; Alkaabi, Nawal; Zaher, Walid Abbas
• Is Part Of: Current medical research and opinion. Volume 38:Number 12(2022)
• Page Start: 2069
• Page End: 2075
• Publication Date: 2022-12-02
• Subjects: SARS-CoV-2 -- IgG -- neutralizing antibodies -- BBIBP-CorV -- inactivated vaccines -- COVID-19 -- UAE -- retrospective study; Clinical medicine -- Periodicals; Therapeutics -- Periodicals; 615.5
• DOI: 10.1080/03007995.2022.2139969
• Languages: English
• ISSNs: 0300-7995

Abstract

Abstract: Background: Breakthrough infections post-COVID-19 vaccination occur with the emerging variants of the SARS-CoV virus which might be either due to the newer variants escaping immune response or the waning of antibodies over time. However, there is lack of long-term follow-up evidence on the waning of immune response following inactivated COVID-19 vaccine. Methods: A retrospective, observational study was conducted on serum samples of individuals who had received two doses of BBIBP-CorV vaccine. Individual's antibody responses were evaluated based on IgG anti-S and neutralizing antibodies measurements. Antibody samples were categorized into four groups, defined by the time interval from the individual's receipt of the BBIBP-CorV vaccine: <30 days, 30–90 days, 91–180 days and >180 days. Results: A total of 6668 serum samples from inactivated BBIBP-CorV vaccine recipients were analyzed for IgG anti-S and neutralizing antibodies. 571 (8.6%) samples were tested during the first 29 days interval post vaccination, 3642 (54.6%) were tested during 30–90 days interval, 2173 (32.6%) samples were tested during 91 to 180 days interval and 282(4.2%) were tested at >180 days interval post vaccination. We found that more than 50% of the individuals had antibody titers below the average cut-off range at the 91–180 days interval post vaccination. Older age (>60 years), male gender, chronic kidney disease, hypertension, immunodeficiencies and increased interval post vaccination emerged as independent risk factors associated with lower immune response. Conclusion: Inactivated BBIBP-CorV vaccine recipients, based on age, gender and associated comorbid conditions might need booster doses at an earlier interval than the currently followed six months interval.