Real-world impact and effectiveness of the quadrivalent HPV vaccine: an updated systematic literature review. (2nd December 2022)

• Record Type: Journal Article
• Authors: Wang, Wei (Vivian); Kothari, Smita; Skufca, Jozica; Giuliano, Anna R.; Sundström, Karin; Nygård, Mari; Koro, Carol; Baay, Marc; Verstraeten, Thomas; Luxembourg, Alain; Saah, Alfred J.; Garland, Suzanne M.
• Is Part Of: Expert review of vaccines. Volume 21:Number 12(2022)
• Page Start: 1799
• Page End: 1817
• Publication Date: 2022-12-02
• Subjects: Cancer -- HPV -- HPV infection -- vaccine effectiveness -- vaccine impact; Vaccines -- Periodicals; Vaccination -- Periodicals; 615.37205
• DOI: 10.1080/14760584.2022.2129615
• Languages: English
• ISSNs: 1476-0584

Abstract

ABSTRACT: Introduction: Human papillomavirus (HPV) infection, which poses significant disease burden, is decreasing following implementation of vaccination programs. Synthesized evidence on HPV vaccine real-world benefit was published in 2016. However, long-term impact of vaccination, and how vaccination programs influence infection rates and disease outcomes, requires further examination. Areas covered: We systematically reviewed observational studies on HPV vaccination within MEDLINE, EMBASE, and Google Scholar from 2016 to 2020, involving 14 years of follow-up data. We identified 138 peer-reviewed publications reporting HPV vaccine impact or effectiveness. Outcomes of interest included rates of infection at different anatomical sites and incidence of several HPV-related disease endpoints. Expert opinion: The expansion of HPV vaccination programs worldwide has led to a reduction in genital infection and significant decreases in incidence of HPV-related disease outcomes. Therefore, the WHO has set goals for the elimination of cervical cancer as a public health concern. To track progress toward this requires an understanding of the effectiveness of different vaccination initiatives. However, the impact on males, and potential benefit of gender-neutral vaccination programs have not been fully explored. To present an accurate commentary on the current outlook of vaccination and to help shape policy therefore requires a systematic review of available data.