A triphenylphosphine coordinated Cu(i) Fenton-like agent with ferrocene moieties for enhanced chemodynamic therapy. Issue 47 (14th November 2022)

• Record Type: Journal Article
• Authors: Zhong, Jingjing; Hong, Zhaoguo; Huang, Sudi; Zhong, Qiongqiong; Zhang, Liangliang; Zhao, Shulin; Liang, Hong; Huang, Fu-Ping
• Is Part Of: Dalton transactions. Volume 51:Issue 47(2022)
• Page Start: 18054
• Page End: 18058
• Publication Date: 2022-11-14
• Subjects: Chemistry, Inorganic -- Periodicals; Chemistry, Physical and theoretical -- Periodicals; Chemistry, Inorganic -- Periodicals; 546.05
• DOI: 10.1039/d2dt03088h
• Languages: English
• ISSNs: 1477-9226

Abstract

Abstract : A Triphenylphilosophy Coordinated Cu (i ) CDT Agent (Fc OD Cu ) with Ferrocene Moieties was rationally constructed, its CDT efficiency is higher than that of Ba OD Cu (without ferrocene moods) and Fc OD (without Cu (i ) moods). Abstract : A triphenylphosphine coordinated Cu(i ) complex of Fc-OD-Cu was rationally designed for chemodynamic therapy (CDT) of cancer. The complex was capable of generating a highly toxic hydroxyl radical (˙OH) via a Fenton-like reaction induced by Cu(i ) moieties and simultaneously mediated by ferrocene moieties. As a result, the CDT efficiency of Fc-OD-Cu is higher than that of Ba-OD-Cu (without ferrocene moieties) and Fc-OD (without Cu(i ) moieties).