How to prepare and manage a systematic review and meta-analysis of clinical studies. Issue 5 (28th May 2019)

• Record Type: Journal Article
• Authors: Berstock, James R.; Whitehouse, Michael R.
• Is Part Of: EFORT open reviews. Volume 4:Issue 5(2019)
• Page Start: 213
• Page End: 220
• Publication Date: 2019-05-28
• Subjects: systematic review -- meta-analysis -- review -- orthopaedics; Orthopedics -- Periodicals; Musculoskeletal system -- Periodicals; Musculoskeletal system -- Wounds and injuries -- Periodicals; 616.7
• DOI: 10.1302/2058-5241.4.180049
• Languages: English
• ISSNs: 2058-5241

Abstract

Abstract : Use the PICO framework to formulate a specific clinical question. Formulate a search strategy. Prospectively register the review protocol. Execute the literature search. Apply eligibility criteria to exclude irrelevant studies. Extract data and appraise each study for risk of bias and external validity. Provide a narrative review. If appropriate data are available, perform a meta-analysis. Report the review findings in the context of the risk of bias assessment, any sensitivity analyses and the analysis of risk of publication bias. Useful resources include the Cochrane Handbook, PROSPERO, GRADE and PRISMA. Cite this article: EFORT Open Rev 2019;4:213-220. DOI: 10.1302/2058-5241.4.180049