Growth and remodeling in the pulmonary autograft: Computational evaluation using kinematic growth models and constrained mixture theory. (24th November 2021)

• Record Type: Journal Article
• Authors: Vastmans, Julie; Maes, Lauranne; Peirlinck, Mathias; Vanderveken, Emma; Rega, Filip; Kuhl, Ellen; Famaey, Nele
• Is Part Of: International journal for numerical methods in biomedical engineering. Volume 38:Number 1(2022)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2021-11-24
• Subjects: constrained mixture theory -- growth and remodeling models -- kinematic growth -- pulmonary autograft; Biomedical engineering -- Periodicals; Imaging systems in medicine -- Periodicals; Numerical analysis -- Periodicals; Engineering mathematics -- Periodicals; 610.28
• DOI: 10.1002/cnm.3545
• Languages: English
• ISSNs: 2040-7939

Abstract

Abstract: Computational investigations of how soft tissues grow and remodel are gaining more and more interest and several growth and remodeling theories have been developed. Roughly, two main groups of theories for soft tissues can be distinguished: kinematic‐based growth theory and theories based on constrained mixture theory. Our goal was to apply these two theories on the same experimental data. Within the experiment, a pulmonary artery was exposed to systemic conditions. The change in diameter was followed‐up over time. A mechanical and microstructural analysis of native pulmonary artery and pulmonary autograft was conducted. Whereas the kinematic‐based growth theory is able to accurately capture the growth of the tissue, it does not account for the mechanobiological processes causing this growth. The constrained mixture theory takes into account the mechanobiological processes including removal, deposition and adaptation of all structural constituents, allowing us to simulate a changing microstructure and mechanical behavior. Abstract : Within this work, the two main types of growth and remodeling models, kinematic based growth and growth based on constrained mixture theory, are compared by applying them on the same experimental data. In this experiment, a pulmonary artery was placed in aortic position and its deformation and changing microstructure and mechanical behavior was tracked over time. Kinematic growth models were capable of describing the changing deformation. Constrained mixture theory was also able to predict changing microstructure and changing mechanical behavior.