Ruthenium (II)‐Coordinated Supramolecular Metallodrug Complex Realizing Oxygen Self‐Supply In Situ for Overcoming Hypoxic Tumors. (26th August 2021)

• Record Type: Journal Article
• Authors: Liu, Chengfei; Li, Muqiong; Li, Pengxiang; Bai, Yang; Pang, Jun; Fan, Li; Tian, Wei
• Is Part Of: Advanced functional materials. Volume 31:Number 47(2021)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2021-08-26
• Subjects: host–guest interactions -- oxygen self‐supply -- pillararene -- supramolecular metallodrug complexes; Materials -- Periodicals; Chemical vapor deposition -- Periodicals; 620.11
• DOI: 10.1002/adfm.202105837
• Languages: English
• ISSNs: 1616-301X

Abstract

Abstract: Tumor hypoxia greatly limits the antitumor therapeutic efficacy of oxygen (O2 )‐dependent treatments. The common strategies of doping O2 generating compounds into one "package" may lead to insufficient O2 supply in situ in cancer cells due to the relatively low loading content, limited reproducibility, and uncontrollable release kinetics. Herein, organometallic drug complexes combined with a supramolecular interaction strategy are proposed to realize a stable and efficient O2 self‐supply in situ for overcoming hypoxic tumors. A ruthenium (II)‐coordinated supramolecular metallodrug complex (RuSMDC) is first designed and synthesized via host–guest interactions between two functionalized drug molecules, in which ruthenium is used to catalyze the decomposition of hydrogen peroxide to produce O2 . The obtained RuSMDC further self‐assembles into Ru‐containing supramolecular metallodrug micelles (RuSMDMs), which provides sufficient O2 for chemotherapy and photodynamic therapy (PDT) oncotherapy in an anaerobic tumor environment. In vitro and in vivo studies further confirm that RuSMDMs effectively alleviate the tumor hypoxic environment, greatly improve the therapeutic effect of chemotherapy and PDT oncotherapy, and reduce the systemic toxicity to normal organs. Abstract : A ruthenium (II)‐coordinated supramolecular metallodrug complex is first designed, which can further self‐assemble into Ru‐containing supramolecular metallodrug micelles, providing sufficient oxygen for the chemotherapy and photodynamic therapy oncotherapy in anaerobic tumor environment.