Intracellular Condensates of Oligopeptide for Targeting Lysosome and Addressing Multiple Drug Resistance of Cancer (Adv. Mater. 1/2022). Issue 1 (7th January 2022)

• Record Type: Journal Article
• Authors: Wang, Jing; Hu, Liangbo; Zhang, Hongyue; Fang, Yu; Wang, Tingliang; Wang, Huaimin
• Is Part Of: Advanced materials. Volume 34:Issue 1(2022)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2022-01-07
• Subjects: hydrogels -- lysosomal membrane permeabilization -- multidrug resistance -- peptides -- self‐assembly; Materials -- Periodicals; Chemical vapor deposition -- Periodicals; 620.11
• DOI: 10.1002/adma.202270005
• Languages: English
• ISSNs: 0935-9648

Abstract

Abstract : Artificial Biomolecular Condensates In article number 2104704, Huaimin Wang and co‐workers report a general approach for constructing artificial biomolecular condensates of oligopeptide in living cells. The rationally designed aromatic‐capped peptides can reversibly form a nanofibrous hydrogel with a change of the conformation and morphologies in the lysosome. The formed condensates undergo swelling in the lysosome, leading to lysosomal membrane permeabilization and re‐direction of therapeutic drugs to the target.