Excessive gestational weight gain during the week prior to delivery as a predictor of maternal life‐threatening complications in preeclamptic women. Issue 10 (12th July 2021)

• Record Type: Journal Article
• Authors: Morikawa, Mamoru; Saito, Yoshihiro; Mayama, Michinori; Noshiro, Kiwamu; Nakagawa‐Akabane, Kinuko; Umazume, Takeshi; Chiba, Kentaro; Watari, Hidemichi
• Is Part Of: Journal of obstetrics and gynaecology research. Volume 47:Issue 10(2021)
• Page Start: 3498
• Page End: 3508
• Publication Date: 2021-07-12
• Subjects: diuretics -- gestational weight gain -- preeclampsia -- pregnancy -- pulmonary edema; Gynecology -- Periodicals; Obstetrics -- Periodicals; 618.1005
• DOI: 10.1111/jog.14933
• Languages: English
• ISSNs: 1341-8076

Abstract

Abstract: Aim: To investigate the relationship between excessive gestational weight gain during the week prior to delivery (GWG) and severe morbidity and pregnancy termination among pregnant women with preeclampsia (hypertension with proteinuria). Methods: We compared GWG, laboratory data, and complication(s) between 94 preeclamptic women (preeclampsia group) with singleton pregnancies who delivered at ≥22 gestational weeks and 188 healthy women (control group) with singleton pregnancies undergoing elective cesarean deliveries. The gestational weeks at delivery were matched in the preeclampsia and control groups. Results: Among 282 total participants, median of GWG was significantly higher in the preeclampsia group than in the control group (1.6 kg vs. 0.5 kg, p < 0.0001). Furthermore, the GWG cutoff value for the preeclampsia group was 1.6 kg. The odds ratio for morbidity of preeclampsia among the women with GWG ≥1.6 kg at delivery was 12.5 (95% confidence interval, 6.31–24.5). In the preeclampsia group, 47 women with GWG ≥1.6 kg had significantly higher risks of hypoproteinemia, proteinuria, and renal dysfunction than those of 47 women with GWG < 1.6 kg. While, multivariate analysis showed 1.5 kg was a GWG cutoff value for predicting maternal morbidity ( p < 0.0001); preeclamptic women with GWG ≥1.5 kg had a significantly higher risk of pulmonary edema than preeclamptic women with GWG < 1.5 kg (odds ratio, 7.77; 95% confidence interval, 1.64–36.7). Conclusion: Excessive GWG in women with preeclampsia might be a predictor for severe maternal life‐threatening complications requiring pregnancy termination.