Aerobic training mitigates the negative impact of diabetes on fertility. (8th November 2021)

• Record Type: Journal Article
• Authors: Saremi, Abbas; Yousefvand, Zahra; Parastesh, Mohammad; Bayat, Mohammad; Gahreman, Daniel
• Is Part Of: Andrologia. Volume 54:Number 1(2022)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2021-11-08
• Subjects: diabetes mellitus -- exercise -- infertility -- malondialdehyde -- protamines; Andrology -- Periodicals; Infertility, Male -- Periodicals; 616.69
• DOI: 10.1111/and.14306
• Languages: English
• ISSNs: 0303-4569

Abstract

Abstract: Diabetes negatively affects the reproductive system. This present study investigated the effects of aerobic training on protamine 1 and 2 mRNA expression, sex hormones, antioxidant defence and sperm quality in diabetic rats. Thirty‐six male Wistar rats were randomly allocated into three groups including diabetic training (DT) group, diabetic (D) group and control (C) group. Rats in DT were exercised 5 times per week for 8 weeks. Blood samples were collected for evaluation of sex hormones 48 h after the last training session. Also, the testes were removed and subjected to histological evaluation and semen analysis. Testicular mRNA expressions of protamines were determined by RT‐qPCR. Protamines 1 and 2, and the ratio of protamine 1 to protamine 2 were significantly lower in DT and D groups compared with C group ( p < 0.01). LH and testosterone levels were significantly lower in D group compared with DT and C group ( p < 0.01). Malondialdehyde was significantly lower in DT and C groups compared with D group ( p < 0.001). Sperm parameters were significantly lower in D group compared with C group ( p < 0.01). Our findings suggest that aerobic training may mitigate the negative impact of diabetes on sex hormones, oxidative stress, protamine content and sperm parameters in male rats.