Biomimetic, Stiff, and Adhesive Periosteum with Osteogenic–Angiogenic Coupling Effect for Bone Regeneration. Issue 14 (11th March 2021)

• Record Type: Journal Article
• Authors: Yang, Yuhe; Xu, Tianpeng; Zhang, Qiang; Piao, Yun; Bei, Ho Pan; Zhao, Xin
• Is Part Of: Small. Volume 17:Issue 14(2021)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2021-03-11
• Subjects: angiogenesis -- osteogenesis -- periosteum -- stiffness -- tissue adhesiveness; Nanotechnology -- Periodicals; Nanoparticles -- Periodicals; Microtechnology -- Periodicals; 620.5
• DOI: 10.1002/smll.202006598
• Languages: English
• ISSNs: 1613-6810

Abstract

Abstract: Current periosteal grafts have limitations related to low mechanical strength, tissue adhesiveness, and poor osteogenesis and angiogenesis potential. Here, a periosteum mimicking bone aid (PMBA) with similar structure and function to natural periosteum is developed by electrospinning photocrosslinkable methacrylated gelatin (GelMA), l ‐arginine‐based unsaturated poly(ester amide) (Arg‐UPEA), and methacrylated hydroxyapatite nanoparticles (nHAMA). Such combination of materials enhances the material mechanical strength, favors the tissue adhesion, and guarantees the sustained activation of nitric oxide–cyclic guanosine monophosphate (NO–cGMP) signaling pathway, with well‐coordinated osteogenic–angiogenic coupling effect for accelerated bone regeneration. This work presents a proof‐of‐concept demonstration of thoroughly considering the progression of implant biomaterials: that is, the initial material components (i.e., GelMA, Arg‐UPEA, and nHAMA) equip the scaffold with suitable structure and function, while its degradation products (i.e., Ca 2+ and l ‐arginine) are involved in long‐term mediation of physiological activities. It is envisioned that the strategy will inspire the design of high‐performance bioscaffolds toward bone and periosteum tissue engineering. Abstract : A periosteum mimicking bone aid (PMBA) with superior mechanical and bioactive properties is developed. The methacrylated gelatin (GelMA) and l ‐arginine‐based unsaturated poly(ester amide) (Arg‐UPEA) equip PMBA with superior adhesion properties, while the methacrylated hydroxyapatite nanoparticles (nHAMA) significantly increase its mechanical performances. Calcium ions and l ‐arginine release can coordinate to coactivate nitric oxide–cyclic guanosine monophosphate (NO–cGMP) signaling pathway and achieve osteogenic–angiogenic coupling effect.