Management of lytic bone disease in lymphoplasmacytic lymphoma: A case report and review of the literature. Issue 12 (7th December 2021)

• Record Type: Journal Article
• Authors: Baksh, Mizba; Jiang, Liuyan; Bhatia, Unnati; Alegria, Victoria; Sher, Taimur; Roy, Vivek; Chanan‐Khan, Asher; Ailawadhi, Sikander; Parrondo, Ricardo D.
• Is Part Of: Clinical case reports. Volume 9:Issue 12(2021)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2021-12-07
• Subjects: IgM myeloma -- lymphoplasmacytic lymphoma -- lytic bone lesions -- multiple myeloma -- non‐Hodgkin's lymphoma -- Waldenström macroglobulinemia; Medicine -- Periodicals; 616.09
• DOI: 10.1002/ccr3.5181
• Languages: English
• ISSNs: 2050-0904

Abstract

Abstract: Waldenström macroglobulinemia (WM)/lymphoplasmacytic lymphoma (LPL) is often differentiated from myeloma based on the presence of lytic bone lesions (LBL). However, WM/LPL can present with LBL, and management is poorly understood. We describe a case of an 81‐year‐old woman with LPL who presented with LBL and was successfully treated with chemoimmunotherapy. Abstract : We have discussed how optimal therapeutic management of WM patients with lytic bone disease is poorly understood which necessitates the need for further investigation on the ability of novel agents and anti‐resorptive agents to reverse bone turnover in WM/LPL patients.