An improved method to estimate absolute blood volume based on dialysate dilution. Issue 9 (13th May 2021)

• Record Type: Journal Article
• Authors: Kron, Susanne; Schneditz, Daniel; Keane, David F.; Leimbach, Til; Kron, Joachim
• Is Part Of: Artificial organs. Volume 45:Issue 9(2021)
• Page Start: E359
• Page End: E363
• Publication Date: 2021-05-13
• Subjects: absolute blood volume -- blood volume monitoring -- chronic hemodialysis -- dialysate dilution -- volume management; Artificial organs -- Periodicals; 617.956
• DOI: 10.1111/aor.13970
• Languages: English
• ISSNs: 0160-564X

Abstract

Abstract: Online hemodiafiltration machines equipped with a blood volume monitor and the possibility to rapidly infuse exact amounts of ultrapure dialysate into the extracorporeal circulation can be used to determine absolute blood volume in clinical practice. The aim of the present study was to evaluate the reproducibility of such measurements. Intra‐individual reproducibility was evaluated in four measurements taken in hourly intervals within the same dialysis treatment. Ten patients were studied. Absolute blood volumes measured at the beginning and after 1 hour of dialysis were significantly different (80.6 ± 14.5 and 63.9 ± 14.3 mL/kg, P < .001) and highly reproducible between the last three measurements (63.9 ± 14.3, 61.4 ± 13.8, and 60.9 ± 13.9 mL/kg, P = n.s.). Measurement of absolute blood volume after 1 hour of treatment is more precise than earlier measurements and might be better suited for guidance of ultrafiltration. Abstract : Online hemodiafiltration machines equipped with a blood volume monitor and the possibility to rapidly infuse exact amounts of ultra‐pure dialysate into the extracorporeal circulation can be used to determine absolute blood volume in clinical practice. Absolute volumes measured at the beginning and after one hour of dialysis were significantly different. Therefore, measurement of absolute blood volume should be done earliest after one hour of treatment.