A prognostic approach on a case of pediatric Philadelphia chromosome‐positive acute lymphoblastic leukemia with monosomy‐7. Issue 12 (26th December 2021)

• Record Type: Journal Article
• Authors: Skhoun, Hanaa; Khattab, Mohammed; Belkhayat, Aziza; Takki Chebihi, Zahra; Dakka, Nadia; El Baghdadi, Jamila
• Is Part Of: Clinical case reports. Volume 9:Issue 12(2021)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2021-12-26
• Subjects: ALL -- childhood -- monosomy‐7 -- patient outcome -- Philadelphia‐Positive; Medicine -- Periodicals; 616.09
• DOI: 10.1002/ccr3.5207
• Languages: English
• ISSNs: 2050-0904

Abstract

Abstract: In this work, we present the first case of a Ph‐positive ALL Moroccan girl with t (9;22)(q34;q11) and monosomy‐7. She was diagnosed with Ph‐positive ALL based on bone marrow examination, immunophenotyping, and cytogenetic analysis. She relapsed after treatment with the persistence of the Ph chromosome and the appearance of a monosomy‐7. Abstract : Our case report highlights the occurrence of monosomy‐7 as a distinct marker of poor outcome in children with Philadelphia‐positive ALL.