CXCL14 is a natural inhibitor of the CXCL12–CXCR4 signaling axis. Issue 12 (11th May 2013)

• Record Type: Journal Article
• Authors: Tanegashima, Kosuke; Suzuki, Kenji; Nakayama, Yuki; Tsuji, Kohei; Shigenaga, Akira; Otaka, Akira; Hara, Takahiko
• Is Part Of: FEBS letters. Volume 587:Issue 12(2013)
• Page Start: 1731
• Page End: 1735
• Publication Date: 2013-05-11
• Subjects: iDCs -- immature dendritic cells -- GPCRs -- G-protein–coupled receptors -- siRNA -- small interfering RNA -- Chemokine -- CXCL14 -- CXCL12 -- CXCR4; Biochemistry -- Periodicals; Biophysics -- Periodicals; Molecular biology -- Periodicals; Biochimie -- Périodiques; Biochemistry; Biophysics; Molecular biology; Periodicals; 572.05
• DOI: 10.1016/j.febslet.2013.04.046
• Languages: English
• ISSNs: 0014-5793

Abstract

Abstract : CXCR4 physically interacts with CXCL14 anti bait coimmunoprecipitation by (View interaction). Abstract : CXCL14 binds to CXCR4 with high affinity. CXCR4 is a major binding component of the CXCL14 receptor. CXCL14 inhibits the CXCL12‐mediated chemotaxis of immune cells.