Treatment age and neurocognitive outcomes following proton beam radiotherapy for pediatric low‐ and intermediate‐grade gliomas. Issue 8 (21st May 2021)

• Record Type: Journal Article
• Authors: Heitzer, Andrew M.; Kahalley, Lisa S.; Minard, Charles G.; Stafford, Claire; Grosshans, David R.; Okcu, M. Fatih; Raghubar, Kimberly P.; Gragert, Marsha; McCurdy, Mark; Warren, Emily H.; Gomez, Jocelyn; Ris, M. Douglas; Paulino, Arnold C.; Chintagumpala, Murali
• Is Part Of: Pediatric blood & cancer. Volume 68:Issue 8(2021)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2021-05-21
• Subjects: cognition -- low‐grade glioma -- pediatric brain tumor -- proton radiotherapy; Tumors in children -- Periodicals; Blood -- Diseases -- Periodicals; Cancer in children -- Periodicals; 618.92
• DOI: 10.1002/pbc.29096
• Languages: English
• ISSNs: 1545-5009

Abstract

Abstract: The relationship between age and neurocognitive functioning following proton beam radiotherapy (PRT) in low‐ and intermediate‐grade gliomas (LIGG) has yet to be examined. Eighteen LIGG patients treated with PRT were prospectively enrolled and received annual neurocognitive evaluations of perceptual/verbal reasoning, working memory, and processing speed postradiotherapy. The median age at diagnosis was 8.2 years (range 1.0–14.7) and the median age at PRT was 9.9 years (range 4.2–17.0). Patients' neurocognitive performance did not change on any measure following PRT ( p ≥ .142). We did not observe significant changes in cognitive function over time among a small group of LIGG patients treated with PRT.