Combinatorial dynamics of protein synthesis time delay and negative feedback loop in NF‐κ B signalling pathway. Issue 5 (15th September 2020)

• Record Type: Journal Article
• Authors: Yan, Fang; Liu, Li; Wang, Qingyun
• Is Part Of: IET systems biology. Volume 14:Issue 5(2020)
• Page Start: 284
• Page End: 291
• Publication Date: 2020-09-15
• Subjects: bifurcation -- proteins -- molecular biophysics -- drugs -- cellular biophysics -- cancer -- oscillations -- patient treatment; NF‐κB signalling pathway -- transcription factor NF‐κB links -- cell fates -- IκBα protein synthesis time delay -- negative feedback loop -- NF‐κB biological oscillation -- immune response -- antiinflammatory drugs -- anticancer drugs -- Hopf bifurcation; Systems biology -- Periodicals; Cell physiology -- Periodicals; Biological systems -- Mathematical models -- Periodicals; Genetics -- Mathematical models -- Periodicals; Computational biology -- Periodicals; 573
• DOI: 10.1049/iet-syb.2020.0034
• Languages: English
• ISSNs: 1751-8849

Abstract

Abstract : The transcription factor NF‐ κ B links immune response and inflammatory reaction and its different oscillation patterns determine different cell fates. In this study, a mathematical model with I κ B α protein synthesis time delay is developed based on the experimental evidences. The results show that time delay has the ability to drive oscillation of NF‐ κ B via Hopf bifurcation. Meanwhile, the amplitude and period are sensitive to the time delay. Moreover, the time delay threshold is a function of four parameters characterising the negative feedback loop. Likewise, the parameters also have effects on the amplitude and period of NF‐ κ B oscillation induced by time delay. Therefore, the oscillation patterns of NF‐ κ B are collaborative results of time delay coupled with the negative feedback loop. These results not only enhance the understanding of NF‐ κ B biological oscillation but also provide clues for the development of anti‐inflammatory or anti‐cancer drugs.