Biophysical Considerations in the Rational Design and Cellular Targeting of Flexible Polymeric Nanoparticles (Adv. Mater. Interfaces 23/2021). Issue 23 (8th December 2021)

• Record Type: Journal Article
• Authors: Farokhirad, Samaneh; Kandy, Sreeja Kutti; Tsourkas, Andrew; Ayyaswamy, Portonovo S.; Eckmann, David M.; Radhakrishnan, Ravi
• Is Part Of: Advanced materials interfaces. Volume 8:Issue 23(2021)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2021-12-08
• Subjects: avidity -- entropy -- Monte Carlo simulation -- nanoparticle flexibility -- polymeric nanoparticles; Materials science -- Periodicals; 620.11
• DOI: 10.1002/admi.202170136
• Languages: English
• ISSNs: 2196-7350

Abstract

Abstract : Flexible Polymeric Nanoparticles In article number 2101290, Samaneh Farokhirad, Ravi Radhakrishnan, and co‐workers explore the biophysical principles behind the effect of shape, chemistry, and flexibility of nanoparticles on multivalent ligand–receptor‐mediated avidity and cellular uptake. The findings help establish rational design principles that confer tension, membrane excess area, and cytoskeletal sensing properties to the nanoparticles, which can be exploited for cell‐specific targeting in nanomedicine applications.