Cutaneous manifestations of lupus erythematosus: a practical clinicopathological review for pathologists. Issue 1 (27th December 2021)

• Record Type: Journal Article
• Authors: Bitar, Carole; Menge, Tyler D; Chan, May P
• Is Part Of: Histopathology. Volume 80:Issue 1(2022)
• Page Start: 233
• Page End: 250
• Publication Date: 2021-12-27
• Subjects: antiphospholipid syndrome -- connective tissue disease -- lupus erythematosus -- plasmacytoid dendritic cells -- vasculitis; Histology, Pathological -- Periodicals; 611.018
• DOI: 10.1111/his.14440
• Languages: English
• ISSNs: 0309-0167

Abstract

Abstract : Accurate diagnosis of connective tissue diseases is often challenging, and relies upon careful correlation between clinical and histopathological features, direct immunofluorescence studies and laboratory work‐up. Lupus erythematosus (LE) is a prototype of connective tissue disease with a variety of cutaneous and systemic manifestations. Microscopically, cutaneous LE is classically characterised by an interface dermatitis although other histopathological patterns also exist, depending upon the clinical presentation, location and chronicity of the skin lesions. In this article, we review the clinical, serological, histopathological and direct immunofluorescence findings in LE‐specific and LE non‐specific skin lesions, with an emphasis upon lesser‐known variants, newly described features and helpful ancillary studies. This review will guide general pathologists and dermatopathologists in accurately diagnosing and subclassifying cutaneous LE. Abstract :