The multifaceted role of CARD9 in inflammatory bowel disease. Issue 1 (6th November 2019)

• Record Type: Journal Article
• Authors: Luo, Ping; Yang, Zhiwen; Chen, Bin; Zhong, Xiaoming
• Is Part Of: Journal of cellular and molecular medicine. Volume 24:Issue 1(2020)
• Page Start: 34
• Page End: 39
• Publication Date: 2019-11-06
• Subjects: CARD9 -- inflammatory bowel disease -- predisposing and protective variants -- therapy; Cytology; Medicine; Molecular Biology; Cytologie -- Périodiques; Médecine -- Périodiques; Biologie moléculaire -- Périodiques; Cytology -- Periodicals; Medicine -- Periodicals; Molecular biology -- Periodicals; 611.01805
• DOI: 10.1111/jcmm.14770
• Languages: English
• ISSNs: 1582-1838

Abstract

Abstract: Inflammatory bowel disease (IBD) involves a dysregulated immune response to the gut microbiota. Emerging evidence has demonstrated that dysfunctions in caspase recruitment domain‐containing protein 9 (CARD9) may contribute to the pathogenesis of IBD. Interestingly, an allelic series of Card9 variants have both a common predisposing and rare protective function in IBD patients. In this review, we provide mechanistic insights into the role of the CARD9 adaptor molecule in intestinal inflammation and determine a potential CARD9‐targeting therapeutic approach against IBD.