Single‐Column‐Based Heck Coupling, Condensation and Alkylation Strategy: Synthesis of 2‐Benzoyl‐2‐alkyl‐2, 3‐dihydro‐1H‐inden‐1‐ones. Issue 46 (7th December 2021)

• Record Type: Journal Article
• Authors: Dorjay Lama, Penang; Bhaskara Rao, Latchipatula; Sreenivasulu, Chinnabattigalla; Ravi Kishore, Dakoju; Satyanarayana, Gedu
• Is Part Of: ChemistrySelect. Volume 6:Issue 46(2021)
• Page Start: 13041
• Page End: 13045
• Publication Date: 2021-12-07
• Subjects: Alkyl benzoyl indanones -- 1, 3 Di-ketone -- Heck Coupling -- Intramolecular Condensation -- Single-column; Chemistry -- Periodicals; 540.5
• DOI: 10.1002/slct.202102811
• Languages: English
• ISSNs: 2365-6549

Abstract

Abstract: An efficient method for the synthesis of alkyl benzoyl indanones via a simple intermolecular Heck coupling followed by intramolecular condensation, and alkylation is presented. Notably, the strategy exhibited good substrate scope and enabled the synthesis of diverse alkyl substituted 1, 3‐dicarbonyl products. Significantly, this protocol was successful using a single‐column purification technique. Abstract : An efficient method for the synthesis of alkyl benzoyl indanones via a simple intermolecular Heck coupling followed by intramolecular condensation, and alkylation is presented. Notably, the strategy exhibited good substrate scope and enabled the synthesis of diverse alkyl substituted 1, 3‐dicarbonyl products. Significantly, this protocol was successful using a single‐column purification technique.