Epigenetics in hepatocellular carcinoma. (November 2022)

• Record Type: Journal Article
• Authors: Nagaraju, Ganji Purnachandra; Dariya, Begum; Kasa, Prameswari; Peela, Sujatha; El-Rayes, Bassel F.
• Is Part Of: Seminars in cancer biology. Volume 86(2023)Part 3
• Page Start: 622
• Page End: 632
• Publication Date: 2022-11
• Subjects: 5-Aza 5-azacitidine -- 5-FU 5-fluorouracil -- ACOT12 Acyl CoA thioesterases 12 -- CeRNA competing endogenous RNA -- CHB chronic hepatitis B virus -- CGI CpG island sites -- CIMP CpG island methylator phenotype -- circRNA circular RNA -- CpG cytosine guanine sites -- DNMTs DNA methyltransferases -- DNMTi DNA methyltransferases inhibitor -- EMT epithelial mesenchymal transition -- EZH2 enhancer zesta homolog -- HATS histone acetyl transferases -- HCC hepatocellular carcinoma -- HDACs histone deacetylases -- HDACi histone deacetylase inhibitors -- HDMs histone demethylase -- HGF hepatocyte growth factor -- HIF-1α hypoxia inducible factor-1 alpha -- HMT histone methyltransferases -- ICGC international cancer genome consortium -- ncRNA noncoding RNA -- lncRNA long noncoding RNA -- LSD lysine specific demethylase -- M6A N6-methyladenosine -- MBPs methylbinding protein -- MTA metastasis associated protein -- OPN osteopontin -- PPS protein phosphatases -- PRMT6 protein methyltransferases -- siRNA small interfering RNA -- sncRNA short noncoding RNA -- SNHG small nucleolar RNA host gene -- TCGA the cancer genome atlas -- UCA1 urothelial cancer associated 1 -- WTAP wilms tumour 1- associated protein; Biomarkers -- DNA methylation -- Epidrugs -- Epigenetics -- Hepatocellular carcinoma -- Histone modification -- ncRNAs; Cancer -- Periodicals; Neoplasms -- Periodicals; Review Literature; Cancer -- Périodiques; Electronic journals; 616.994
• DOI: 10.1016/j.semcancer.2021.07.017
• Languages: English
• ISSNs: 1044-579X

Abstract

Highlights: Hepatocellular carcinoma (HCC) is the most common primary liver cancer worldwide. The epigenetic alterations contribute to the differences in HCC genomes. The epigenetic effectors effect the chromatin structure and function of HCC. Epidrugs are promising therapeutic inhibitors for HCC progression. Abstract: Hepatocellular carcinoma (HCC) is the most common primary malignancy of the liver and has a high fatality rate. Genetic and epigenetic aberrations are commonly observed in HCC. The epigenetic processes include chromatin remodelling, histone alterations, DNA methylation, and noncoding RNA (ncRNA) expression and are connected with the progression and metastasis of HCC. Due to their potential reversibility, these epigenetic alterations are widely targeted for the development of biomarkers. In-depth understanding of the epigenetics of HCC is critical for developing rational clinical strategies that can provide a meaningful improvement in overall survival and prediction of therapeutic outcomes. In this article, we have summarised the epigenetic modifications involved in HCC progression and highlighted the potential biomarkers for diagnosis and drug development.