Carcinogenic microbiota and its role in colorectal cancer development. (November 2022)

• Record Type: Journal Article
• Authors: Karpiński, Tomasz M.; Ożarowski, Marcin; Stasiewicz, Mark
• Is Part Of: Seminars in cancer biology. Volume 86(2023)Part 3
• Page Start: 420
• Page End: 430
• Publication Date: 2022-11
• Subjects: Akt protein kinase B -- AMPK AMP-activated protein kinase -- ANGPTL4 angiopoietin-like 4 protein -- Bax Bcl-2-associated X protein -- Bcl-2 B-cell lymphoma 2 -- Bcl-xl B-cell lymphoma-extra large -- CCL3 C-C motif chemokine ligand 3 -- CCR5 C-C motif chemokine receptor 5 -- COX-2 cyclooxygenase-2 -- CRC colorectal cancer -- ERK extracellular-regulated kinase -- FIAF fasting-induced adipose factor -- Gal-GalNAc D-galactose-(1-3)-N-acetyl-D-galactosamine -- H2S hydrogen sulfide -- IFN-γ interferon-γ -- IL interleukin, e.g. IL-17 -- LPS lipopolysaccharide -- MAPK mitogen-activated protein kinases -- miR21 microRNA-21 -- MMP-9 matrix metalloprotease 9 -- MYD88 myeloid differentiation factor 88 -- NF-κB nuclear factor kappa B -- p21 cyclin-dependent kinase inhibitor 1 -- PI3K phosphoinositide 3-kinase -- PCWBR2 cell wall binding repeat 2 surface protein of P. anaerobius -- ROS reactive oxygen species -- SMO spermine oxidase -- STAT-3 signal transducer and activator of transcription-3 -- TIGIT T cell immunoreceptor with Ig and ITIM domains -- TLR toll-like receptor -- TNF-α tumor necrosis factor α -- TRAF-6 TNF receptor associated factor 6 -- Treg regulatory T cell -- Wnt Wingless/INT pathway; Carcinogenesis -- Microbiota -- Inflammation -- Antiapoptotic activity -- Cancerogenic compounds; Cancer -- Periodicals; Neoplasms -- Periodicals; Review Literature; Cancer -- Périodiques; Electronic journals; 616.994
• DOI: 10.1016/j.semcancer.2022.01.004
• Languages: English
• ISSNs: 1044-579X

Abstract

Abstract: Colorectal cancer (CRC) is one of the most common malignancies worldwide. The main risk factors for CRC are family history of colon or rectal cancer, familial polyposis syndrome or hereditary nonpolyposis, and chronic inflammatory bowel diseases (ulcerative colitis and Crohn's disease). Recent studies show that the gastrointestinal microbiota play a significant role in colorectal carcinogenesis. In this review we present the microorganisms, whose influence on the development of CRC has been proven: Bacteroides fragilis, Clostridioides and Clostridium spp., Enterococcus faecalis, Escherichia coli, Fusobacterium nucleatum, Helicobacter pylori, Peptostreptococcus anaerobius, Streptococcus bovis group, and sulfate-reducing bacteria. Moreover, the carcinogenic mechanisms of action mediated by the above bacteria are laid out.