Emerging role of nanoparticles in the diagnostic imaging of gastrointestinal cancer. (November 2022)

• Record Type: Journal Article
• Authors: Zhou, Jianfeng; Chen, Lingmin; Chen, Longqi; Zhang, Yonggang; Yuan, Yong
• Is Part Of: Seminars in cancer biology. Volume 86(2023)Part 2
• Page Start: 580
• Page End: 594
• Publication Date: 2022-11
• Subjects: GI gastrointestinal -- CT computed tomography -- MRI magnetic resonance imaging -- PET positron emission tomography -- IGS image-guided surgery -- EC esophageal cancer -- GC gastric cancer -- LC liver cancer -- GBC gallbladder cancer -- PC pancreatic cancer -- CRC colorectal cancer -- QDs quantum dots -- MNPs magnetic iron oxide nanoparticles -- SPIONs superparamagnetic iron oxide nanoparticles -- AuNPs gold nanoparticles -- SERS surface-enhanced Raman scattering -- UCNPs up-converting nanoparticles -- CNs carbon nanoparticles -- LNPs lipid nanoparticles -- NIR near-infrared -- NIRF near-infrared fluorescence -- GFNPs gadofullerene nanoparticles -- GdNP gadolinium nanoparticle -- PAI photoacoustic imaging -- EPR enhanced permeability and retention; Nanoparticles -- Gastrointestinal cancer -- Diagnosis -- Imaging -- Image-guided surgery; Cancer -- Periodicals; Neoplasms -- Periodicals; Review Literature; Cancer -- Périodiques; Electronic journals; 616.994
• DOI: 10.1016/j.semcancer.2022.04.009
• Languages: English
• ISSNs: 1044-579X

Abstract

Abstract: Gastrointestinal (GI) cancer, which mainly includes tumors of the esophagus, stomach, liver, biliary system, pancreas, and colon, is one of the most common cancers and the dominant cause of cancer-related deaths globally. For the diagnosis of GI cancer, in addition to routine systemic imaging, such as computed tomography (CT), magnetic resonance imaging, and positron emission tomography–CT, locoregional imaging, which covers endoscopy and ultrasound, is also of great concern. However, the current mainstream contrast agents used in these imaging methods have poor specificity, short maintenance time, and severe side effects. In recent years, with the development of nanotechnology, nanoparticles, such as quantum dots, iron oxide nanoparticles, and gold nanoparticles, have offered many benefits in GI cancer imaging owing to their small size, customizable surface properties, and retention effect. An increasing number of studies have combined the traditional methods of imaging digestive tract tumors with nanoparticles, significantly improving the early diagnosis rate and staging accuracy. Here, we review the current evidence on the utilization of nanoparticles in the diagnostic imaging of GI tumors from the aspects mentioned above.