Chemokines driven ovarian cancer progression, metastasis and chemoresistance: Potential pharmacological targets for cancer therapy. (November 2022)

• Record Type: Journal Article
• Authors: Bose, Subhankar; Saha, Priyanka; Chatterjee, Bilash; Srivastava, Amit Kumar
• Is Part Of: Seminars in cancer biology. Volume 86(2023)Part 2
• Page Start: 568
• Page End: 579
• Publication Date: 2022-11
• Subjects: EOC epithelial ovarian cancer -- GPCR G protein-coupled receptor -- CAF cancer-associated fibroblast -- TAM tumor-associated macrophage -- MDSC myeloid-derived suppressor cell -- I-TAC interferon-inducible T cell alpha chemoattractant -- IP-9 interferon-gamma inducible protein 9 -- EMT epithelial-mesenchymal transition -- PFS progression-free survival -- HIF-1 hypoxia-inducible factor-1 -- OCSLC ovarian cancer stem-like cell -- NF-κB nuclear factor kappa B -- SPARC secreted protein acidic and rich in cysteine -- SPARCL1 SPARC like protein 1 -- MSC mesenchymal stromal cells -- OVV oncolytic vaccinia virus -- VEGFR vascular endothelial growth factor receptor -- Treg T regulatory cell -- GM-CSF granulocyte macrophage colony-stimulating factor -- G-CSF granulocyte colony stimulating factor -- Pre DC2 dendritic cell precursor 2 -- FKHR forkhead in rhabdomyosarcoma -- GSK-3β glycogen synthase kinase 3 beta -- IGF-1R insulin like growth factor 1 receptor -- ABCB1 ATP-binding cassette sub-family B member 1; Chemokines -- Chemokine receptors -- Ovarian cancer -- Tumor microenvironment (TME) -- microRNAs (miRNAs); Cancer -- Periodicals; Neoplasms -- Periodicals; Review Literature; Cancer -- Périodiques; Electronic journals; 616.994
• DOI: 10.1016/j.semcancer.2022.03.028
• Languages: English
• ISSNs: 1044-579X

Abstract

Abstract: Ovarian cancer is a leading cause of death among women globally often characterized by poor prognosis and aggressive tumor growth. The therapeutic outcomes of ovarian cancer patients are majorly limited by the development of acquired chemo/radioresistance and the lack of targeted therapies. The tumor microenvironment (TME) comprises a diverse population of cells including adipocytes, fibroblasts, tumor cells, and immune cells which play an imperative role in promoting tumor growth, invasion, and malignant phenotypes of cancer cells. The cells present in TME secrete various inflammatory mediators including chemokines and cytokines, which regulate the tumor progression and metastasis. This review article highlights new insights about the general mechanisms associated with chemokines-mediated cell proliferation, inflammation, tumor initiation, progression, metastasis, chemoresistance, and immune evasion in ovarian cancer. We also discuss the microRNAs (miRNAs) regulating the oncogenic potential of chemokines. Overall, this is a comparatively less explored area that could provide important insights into ovarian cancer development and a promising avenue for targeted therapy of ovarian cancer.