The development and progress of nanomedicine for esophageal cancer diagnosis and treatment. (November 2022)

• Record Type: Journal Article
• Authors: Li, Xiaokun; Chen, Lingmin; Luan, Siyuan; Zhou, Jianfeng; Xiao, Xin; Yang, Yushang; Mao, Chengyi; Fang, Pinhao; Chen, Longqi; Zeng, Xiaoxi; Gao, Huile; Yuan, Yong
• Is Part Of: Seminars in cancer biology. Volume 86(2023)Part 2
• Page Start: 873
• Page End: 885
• Publication Date: 2022-11
• Subjects: EC Esophageal cancer -- ESCC Esophageal squamous cell carcinoma -- EAC Esophageal adenocarcinoma -- EPR Enhanced permeability and retention -- NTRK Neurotrophic tropomyosin receptor kinase -- HER-2 Human epidermal growth factor receptor-2 -- PD-1 Programmed death 1 -- PD-L1 Programmed cell death ligand 1 -- HPV Human papillomavirus -- PEI Poly(ethylenimine) -- PLA Poly(lactic acid) -- TMC-DTX Docetaxel-loaded trimethyl chitosan -- DCMs Disulfide crosslinked micelles -- Re Rhenium -- EGFR Epidermal growth factor receptor -- Nab-paclitaxel Albumin-bound paclitaxel -- TaOx Tantalum oxide -- CT Computed tomography -- CECT Contrast-enhanced computerized tomography -- VEGFR Vascular endothelial growth factor receptor -- FGFR fibroblast growth factor receptor -- SERS Surface-enhanced Raman spectroscopy -- PDT photodynamic therapy -- PTT photothermal therapy -- Doxil Doxorubicin -- EPI Epirubicin -- ATP aptamer-polyethyleneimine -- PLGA poly(lactic-co-glycolic acid) -- DSPE-PEG Distearoyl phosphatidylethanolamine-polyethylene glycol -- PMPNs PEG-TE10@PLGA@DOX-Cur NPs -- PSs Photosensitizers -- BSA bovine serum albumin -- MOFs Metal–organic frameworks -- PZM Porous Zr(IV) porphyrin MOF -- PDA Polydopamine -- PRINT Particle replication in nonwetting template -- FA-PPSM FA-PDA@PZM/SN38@BSA-MnO2; Esophageal cancer -- Nanoparticle -- Nanomedicine -- Imaging -- Drug delivery; Cancer -- Periodicals; Neoplasms -- Periodicals; Review Literature; Cancer -- Périodiques; Electronic journals; 616.994
• DOI: 10.1016/j.semcancer.2022.01.007
• Languages: English
• ISSNs: 1044-579X

Abstract

Abstract: Esophageal cancer (EC) is a common gastrointestinal malignancy with poor prognosis and high mortality. Although combined therapeutic strategies have been developed, the 5-year survival rate of patients with EC remains relatively poor. Conventional anti-cancer drug delivery techniques have some shortcomings, such as nontargeted delivery and nonspecific toxicity. Nanoparticles (NPs) provide a promising platform for delivering drugs in various therapeutic modalities for EC, which possess several remarkable advantages in cancer therapy, such as reduced side effects, prolonged circulation time, and preferential accumulation at the tumor site. In this review, we summarized various types of NPs applied in the treatment of EC, including polymers, micelles, liposomes, inorganic NPs and organic NPs. Meanwhile, we discussed the efficacy and safety of newly designed nanomedicine in various treatments of EC, including chemotherapy, radiotherapy, gene therapy, photodynamic therapy (PDT), photothermal therapy (PTT), and their synergetic therapy. In addition, nanomedicine applied in tumor imaging and diagnoses were also reviewed. Current studies have suggested the potential advantages of nanoformulations over conventional formulations. More researches to promote clinical translation of nanomedicine for EC are anticipated in the future.