Impact of the ileal microbiota on colon cancer. (November 2022)

• Record Type: Journal Article
• Authors: Roberti, Maria Paula; Rauber, Conrad; Kroemer, Guido; Zitvogel, Laurence
• Is Part Of: Seminars in cancer biology. Volume 86(2023)Part 2
• Page Start: 955
• Page End: 966
• Publication Date: 2022-11
• Subjects: APC antigen-presenting cell -- CIMP CpG island methylator phenotype -- CRC colorectal cancer -- dCC distal colon cancer -- pCC proximal colon cancer -- GALT gut-associated lymphoid tissue -- DC dendritic cell -- FMT fecal microbiota transplantation -- IBD inflammatory bowel disease -- ICI immune checkpoint inhibition -- IEC intestinal epithelial cell -- IEL intraepithelial lymphocyte -- LP lamina propria -- mLN mesenteric lymph node -- MMR DNA mismatch repair system -- MSI-H microsatellite instability-hi -- MSS microsatellite stable -- SCFA short-chain fatty acids -- tdLN tumor draining lymph node -- Tfh T follicular helper cell -- TIL Tumor infiltrating lymphocyte -- TLS tertiary lymphoid structures -- TMB tumor mutational burden -- TME tumor microenvironment; Gut microbiota -- Ileum -- Intestinal epithelial cell -- Colon cancer -- Immunotherapy; Cancer -- Periodicals; Neoplasms -- Periodicals; Review Literature; Cancer -- Périodiques; Electronic journals; 616.994
• DOI: 10.1016/j.semcancer.2021.09.016
• Languages: English
• ISSNs: 1044-579X

Abstract

Abstract: Besides tumor cell–intrinsic oncogenic pathways, host and environmental factors have a major impact on cancer immunosurveillance and the efficacy of immunotherapeutics. Several modalities of anticancer treatments including immunogenic chemotherapies and immune checkpoint inhibitors lose their efficacy in patients treated with broad-spectrum antibiotics, pointing to a key role for the gut microbiota. The complex interactions between intestinal microbes, gut immunity and anti-tumor responses constitute an emerging field of investigation. In this work, we revise key primary literature, with an emphasis on recent mechanistic insights, unraveling the interplay between the immunosurveillance of colon cancers and ileal factors including the local microbiota, tissue architecture and immune system.