Histological Markers of Clinical Relapse in Endoscopically Quiescent Ulcerative Colitis. Issue 11 (28th December 2019)

• Record Type: Journal Article
• Authors: Kevans, David; Kirsch, Richard; Dargavel, Callum; Kabakchiev, Boyko; Riddell, Robert; Silverberg, Mark S
• Is Part Of: Inflammatory bowel diseases. Volume 26:Issue 11(2020)
• Page Start: 1722
• Page End: 1729
• Publication Date: 2019-12-28
• Subjects: ulcerative colitis -- clinical relapse -- histology -- basal plasmacytosis -- Geboes score; Inflammatory bowel diseases -- Periodicals; Colitis, Ulcerative -- Periodicals; Crohn Disease -- Periodicals; Inflammatory Bowel Diseases -- Periodicals; 616.344
• DOI: 10.1093/ibd/izz308
• Languages: English
• ISSNs: 1078-0998

Abstract

Abstract: Background: In ulcerative colitis (UC) patients who have achieved mucosal healing, active microscopic colonic mucosal inflammation is commonly observed. We aimed to assess the association between histological activity and disease relapse in endoscopically quiescent UC. Methods: Ulcerative colitis patients with endoscopically quiescent disease and ≥12 months of follow-up were included. Biopsies were reviewed for the presence of basal plasmacytosis (BPC) and active histological inflammation, defined as a Geboes score (GS) ≥3.2. Primary outcome measures were disease relapse at 18 months and time to first relapse after index colonoscopy. Results: Seventy-six UC patients (51% male; mean age, 38.6 years; median follow-up [range], 75.2 [2–118] months) were included. Sixty-two percent had an endoscopic Mayo score of 0 at index colonoscopy. Basal plasmacytosis was present in 46% and active histological inflammation in 30% of subjects. Presence of BPC was associated with a significantly shorter time to disease relapse ( P = 0.01). Active histological inflammation was significantly associated with clinical relapse at 18 months ( P = 0.0005) and shorter time to clinical relapse ( P = 0.0006). Multivariate analysis demonstrated active histological inflammation to be independently associated with clinical relapse at 18 months and time to clinical relapse. Conclusions: In endoscopically quiescent UC, active histological inflammation and the presence of BPC are adjunctive histological markers associated with increased likelihood of disease relapse. Although prospective studies are required, the presence of these histological markers should be a factor considered when making therapeutic decisions in UC. Abstract : In ulcerative colitis (UC) patients achieving mucosal healing, histological activity is commonly observed. We demonstrate an association between histological activity and clinical relapse in endoscopically quiescent disease. Histological activity provides valuable clinical information in patients with endoscopically quiescent UC.