Favorable Outcomes in Older Recipients Receiving Simultaneous Pancreas Kidney Transplantation. Issue 12 (17th November 2022)

• Record Type: Journal Article
• Authors: Budhiraja, Pooja; Heilman, Raymond L.; Reddy, Kunam S.; Jadlowiec, Caroline C.; Khamash, Hassan A.; Ninan, Jacob; Reddy, Swetha; Me, Hay Me; Misra, Suman; Katariya, Nitin; Chakkera, Harini A.
• Is Part Of: Transplantation direct. Volume 8:Issue 12(2022)
• Page Start: e1413
• Publication Date: 2022-11-17
• Subjects: Transplantation of organs, tissues, etc -- Periodicals; Transplantation -- Periodicals; 362.19795
• DOI: 10.1097/TXD.0000000000001413
• Languages: English
• ISSNs: 2373-8731

Abstract

Abstract : Background: The objective of this study was to compare the long-term outcomes of older (50–65 y) type 1 diabetics with body mass index <35 kg/m 2 and type 2 diabetics with body mass index <30 kg/m 2 who received simultaneous pancreas kidney transplantation (SPKT) versus living donor kidney transplants (LDKTs). All subjects had insulin-dependent diabetes. Methods: This is a retrospective single-center study from July 2003 to March 2021 with a median follow-up of 7.5 y. Results: There were 104 recipients in the SPKT and 80 in the LDKT group. The mean age was 56 y in SPKT and 58 y in LDKT. There were 55% male recipients in the SPKT group versus 75% in LDKT. The duration of diabetes was 32 y in SPKT versus 25 y in LDKT. The number of preemptive transplants and length of dialysis were similar. However, the wait time was shorter for LDKT (269 versus 460 d). Forty-nine percent of the LDKT recipients received the organ within 6 mo of being waitlisted compared with 28% of SPKT recipients ( P = 0.001). Donor age was lower in the SPKT group (27 versus 41 y). The estimated 5-y death censored kidney survival was 92% versus 98%, and 5-y patient survival was 86% versus 89% for SPKT versus LDKT. Death censored kidney and patient survival, acute kidney rejection by 1 y, and BK viremia were similar between the 2 groups. There were 17 pancreas graft losses within 1 y of transplant, the majority related to surgical complications, and it was not associated with increased mortality. Conclusions: SPKT in selected recipients aged 50 and above can have excellent outcomes similar to LDKT recipients. Abstract :