Immunological Correlates of Prevention of the Onset of Seasonal H3N2 Influenza. (27th April 2022)

• Record Type: Journal Article
• Authors: Okuda, Moe; Sakai-Tagawa, Yuko; Koga, Michiko; Koibuchi, Tomohiko; Kikuchi, Tadashi; Adachi, Eisuke; Ahyoung Lim, Lay; Yamamoto, Shinya; Yotsuyanagi, Hiroshi; Negishi, Kyota; Jubishi, Daisuke; Yamayoshi, Seiya; Kawaoka, Yoshihiro
• Is Part Of: Journal of infectious diseases. Volume 226:Number 10(2022)
• Page Start: 1800
• Page End: 1808
• Publication Date: 2022-04-27
• Subjects: Influenza A virus -- H3N2 -- correlates of protection -- subclinical infection -- antibody functions that inhibit influenza infection; Communicable diseases -- Periodicals; Diseases -- Causes and theories of causation -- Periodicals; Medicine -- Periodicals; Communicable Diseases -- Periodicals; Electronic journals; 616.9
• DOI: 10.1093/infdis/jiac152
• Languages: English
• ISSNs: 0022-1899

Abstract

Abstract: On influenza virus infection or vaccination, immune responses occur, including the production of antibodies with various functions that contribute to protection from seasonal influenza virus infection. In the current study, we attempted to identify the antibody functions that play a central role in preventing the onset of seasonal influenza by comparing the levels of several antibody titers for different antibody functions between 5 subclinically infected individuals and 16 patients infected with seasonal H3N2 virus. For antibody titers before influenza virus exposure, we found that the nAb titers and enzyme-linked immunosorbent assay titers against hemagglutinin and neuraminidase (NA) proteins in the subclinically infected individuals were significantly higher than those in the patients, whereas the NA inhibition titers and antibody-dependent cellular cytotoxicity activities did not significantly differ between subclinically infected individuals and infected patients. These results suggest that nAb and enzyme-linked immunosorbent assay titers against hemagglutinin and NA serve as correlates of symptomatic influenza infection. Abstract : We identified the antibody functions that play a central role in preventing the onset of seasonal influenza by comparing the levels of several antibody titers between 5 subclinically infected individuals and 16 patients infected with seasonal H3N2 virus.