A supramolecular organometallic drug complex with H2O2 self-provision intensifying intracellular autocatalysis for chemodynamic therapy. Issue 43 (27th October 2022) - Liu, Chengfei
Abstract : A supramolecular organometallic drug complex (SOMDC ) with H2 O2 self-provision was proposed to intensify the intracellular autocatalysis for enhancing the CDT effect. Abstract : Chemodynamic therapy (CDT) can efficiently combat tumor cells through a robust catalyst in the presence of H2 O2 . However, the insufficient intracellular H2 O2 level and inefficiency of catalysts in tumor cells limit the production of enough toxic hydroxyl radicals (˙OH) to achieve satisfactory efficacy for CDT. Herein, a supramolecular organometallic drug complex (SOMDC ) with H2 O2 self-provision was proposed to intensify the intracellular autocatalysis for enhancing the CDT effect. The obtained SOMDC could self-assemble into supramolecular organometallic drug micelles (SOMDMs ), which could be effectively dissociated because the endogenous H2 O2 in tumor cells can rapidly destroy the host–guest interactions. The released DOX prodrug effectively upregulated the endogenous H2 O2 level and amplified the Fenton-like intracellular autocatalysis to guarantee a remarkable ˙OH production for improving CDT efficiency. In vitro and in vivo evaluations showed that SOMDC exhibited excellent anticancer activity with reduced toxicity to normal tissues. Therefore, this novel strategy with H2 O2 self-provision to intensify intracellular autocatalysis for enhancing the CDT effect may provide new insights for cancer therapy.