(±)-Pheharmines A–B, two pairs of racemic alkaloids with a morpholino[4, 3, 2-hi]β-carboline core, from the roots of Peganum harmala. Issue 43 (24th October 2022)

• Record Type: Journal Article
• Authors: Li, Sheng-Ge; Hu, Xu; Zhang, Qin; Zan, Yan-Hui; Wang, Kai-Bo; Jiang, Chun-Yu; Xue, Jing-Jing; Liu, Yong-Xiang; Lin, Bin; Jing, Yong-Kui; Li, Da-Hong; Hua, Hui-Ming
• Is Part Of: Organic & biomolecular chemistry. Volume 20:Issue 43(2022)
• Page Start: 8528
• Page End: 8532
• Publication Date: 2022-10-24
• Subjects: Chemistry, Organic -- Periodicals; Bioorganic chemistry -- Periodicals; Chemistry, Physical organic -- Periodicals; 547
• DOI: 10.1039/d2ob01608g
• Languages: English
• ISSNs: 1477-0520

Abstract

Abstract : Two pairs of unprecedented β-carboline-phenylpropanoid alkaloids, (±)-pheharmines A–B (1–4 ), characterized by a morpholino[4, 3, 2- hi ]β-carboline core with two chiral centers, were isolated from the roots of Peganum harmala . Abstract : Two pairs of unprecedented β-carboline-phenylpropanoid heterogeneous alkaloids, (±)-pheharmines A–B (1–4 ), characterized by a morpholino[4, 3, 2- hi ]β-carboline core with two chiral centers, were isolated from the roots of Peganum harmala . The structures, including their absolute configurations, were identified using spectroscopic analyses and electronic circular dichroism (ECD) calculations. The biosynthetic hypothesis for the formation of pheharmines A–B was proposed. Compounds 1–4 exhibited moderate cytotoxic activities against HL-60 cell lines.