5-Fluoro-1, 2, 3-triazole motif in peptides and its electronic properties. Issue 43 (20th October 2022)

• Record Type: Journal Article
• Authors: Laxio Arenas, José; Retailleau, Pascal; Gillet, Jean-Michel; Ghermani, Nour-Eddine; Ongeri, Sandrine; Crousse, Benoît
• Is Part Of: Organic & biomolecular chemistry. Volume 20:Issue 43(2022)
• Page Start: 8410
• Page End: 8414
• Publication Date: 2022-10-20
• Subjects: Chemistry, Organic -- Periodicals; Bioorganic chemistry -- Periodicals; Chemistry, Physical organic -- Periodicals; 547
• DOI: 10.1039/d2ob01716d
• Languages: English
• ISSNs: 1477-0520

Abstract

Abstract : The 5-fluoro triazole amino acid has been prepared by halogen exchange between the 5-iodo triazole and fluoride salts and incorporated in peptides. X-ray crystallography reveals a cylindrical shape in its deformation electron density. Abstract : The 5-fluoro triazole amino acid scaffold prepared by halogen exchange has been incorporated into peptides. From the X-ray diffraction of the 5-fluoro triazole motif, the main observation was an important localization on one side of the negative potential surface. The fluorine atom reveals a cylindrical shape in its deformation electron density.