Folic acid modified UiO-66 nano drug carrier for combination therapy. (31st October 2022)

• Record Type: Journal Article
• Authors: Xu, Jin; Chen, Li; Shu, Wen; Zhang, Fang-Zhong; Xie, Bao-Xuan; Wang, Hai-Shuang; Wang, Yu-Lin; Lin, Rong-Guang
• Is Part Of: New journal of chemistry. Volume 46:Number 44(2022)
• Page Start: 21428
• Page End: 21433
• Publication Date: 2022-10-31
• Subjects: Chemistry -- Periodicals; Chimie -- Périodiques; 540
• DOI: 10.1039/d2nj02523j
• Languages: English
• ISSNs: 1144-0546

Abstract

Abstract : The drug delivery system which called RB-Drug@UiO-66-FA can release anticancer drugs slowly in an acidic environment, and generate 1 O2 under light exposure, achieving the effect of chemotherapy–photodynamic therapy. Abstract : The metal–organic framework UiO-66 with metal zirconium as the node has been synthesized using zirconium chloride and terephthalic acid. Anticancer drugs (CPT and DOX) and a photosensitizer (RB) were encapsulated via a post-loading method, and then the surface was modified with NH2 -PEG-FA to form RB-Drug@UiO-66-FA. The introduction of folic acid (FA) increased the stability and biocompatibility of the nanomaterials. Through X-ray diffraction and zeta potential analysis, we confirm that the modified material maintains its original structure and can effectively encapsulate the drug. By testing its performance, we showed that the drugs were released at high levels in the acidic environment where cancer cells survive. After 552 nm laser irradiation, a large amount of 1 O2 was produced, promoting apoptosis. These results indicated that the materials demonstrate a good, combined effect of chemotherapy and photodynamic therapy.