Metabolic syndrome components and leukocyte telomere length in patients with major depressive disorder. (3rd July 2022)

• Record Type: Journal Article
• Authors: Huang, Yu-Chi; Lin, Pao-Yen; Lee, Yu; Lee, Chun-Yi; Lo, Yi-Ching; Hung, Chi-Fa; Chen, Cheng-Sheng
• Is Part Of: World journal of biological psychiatry. Volume 23:Number 6(2022)
• Page Start: 483
• Page End: 492
• Publication Date: 2022-07-03
• Subjects: Ageing -- telomere -- metabolic syndrome -- depression -- HDL-C; Biological psychiatry -- Periodicals; Biological Psychiatry -- Periodicals; 616.89
• DOI: 10.1080/15622975.2021.2013091
• Languages: English
• ISSNs: 1562-2975

Abstract

Abstract: Objectives: The relationship between metabolic syndrome (MetS) components and leukocyte telomere length (LTL) attrition in major depressive disorder (MDD) remains unclear. Methods: We recruited 70 MDD patients (mean age: 44.6 years, 60.0% female) and 51 age- and sex-matched controls (mean age: 41.2 years, 68.6% female) to examine the associations of MetS components and LTL. Five MetS components—waist circumference, systolic/diastolic blood pressure, serum levels of fasting glucose, high-density lipoprotein cholesterol (HDL-C), and triglycerides—were assessed. LTL was measured through quantitative polymerase chain reaction. Results: MDD had higher prevalence of MetS (34.3 vs. 17.6%, p =.042), low HDL-C (25.7 vs. 7.8%, p =.009) and shorter LTL (-0.038 ± 0.169 vs. 0.033 ± 0.213, p =.042). Regression analysis revealed that MDD ( p =.046) and age ( p =.003) associated with LTL, while a significant interaction effect of group (MDD vs. controls) × HDL-C ( p =.037) was observed. Post-hoc analysis showed MDD with low HDL-C had greater LTL attrition than controls without low HDL-C ( p =.020). In MDD, HDL-C dysregulation negatively correlated with LTL ( p =.010); but no significance after Bonferroni correction. Conclusions: HDL-C may be involved in accelerated ageing process regarding metabolic disturbance in MDD only. The relationship merits prospective investigations with larger sample size for clarification.