Efficacy of Biosimilar Adalimumab in the Treatment of Behçet's Uveitis. (18th August 2022)

• Record Type: Journal Article
• Authors: Soheilian, Masoud; Ebrahimiadib, Nazanin; Hedayatfar, Alireza; Hosseini, Maryam; Zarei, Mohammad; Anjidani, Nassim
• Is Part Of: Ocular immunology and inflammation. Volume 30:Number 6(2022)
• Page Start: 1495
• Page End: 1500
• Publication Date: 2022-08-18
• Subjects: Adalimumab -- Behçet's disease -- uveitis -- TNF-alpha -- biosimilar -- efficacy -- biADA; Eye -- Diseases -- Immunological aspects -- Periodicals; Eye -- Inflammation -- Periodicals; 617.7
• DOI: 10.1080/09273948.2021.1900276
• Languages: English
• ISSNs: 0927-3948

Abstract

ABSTRACT: Purpose: This study aimed to evaluate biosimilar adalimumab's efficacy and safety in patients with Behçet's uveitis in Iran. Methods: We performed a study on patients who mostly (79.2%) had a failure on conventional treatment with the mean follow-up time of 19.24 months (95% confidence interval (CI), 16.52–21.96). All the enrolled patients were anti-tumor necrosis factor (anti-TNF) naiive. The primary endpoint was best-corrected visual acuity (BCVA) improvement, and the secondary endpoints were changes in macular thickness, vitreous haze grade, anterior chamber (AC) cell grade, prednisolone dose, and the incidence of adverse reactions. Results: Forty-eight patients were enrolled in the study. After adalimumab use, visual acuity improved significantly ( p -value˂.001); vitreous haze grade decreased ( p -value˂.001), and AC cell grade improved ( p -value = .002). Macular thickness decreased, but its change was not statistically significant ( p -value = .1). Moreover, adalimumab showed a corticosteroid-sparing effect ( p -value = .03). Conclusion: Biosimilar adalimumab (CinnoRA®) is effective and well-tolerated in Behçet's uveitis.