Clonal hematopoiesis in clinical practice: walking a tightrope. Issue 11 (19th September 2022)

• Record Type: Journal Article
• Authors: Tarantini, Francesco; Cumbo, Cosimo; Anelli, Luisa; Zagaria, Antonella; Coccaro, Nicoletta; Tota, Giuseppina; Specchia, Giorgina; Musto, Pellegrino; Albano, Francesco
• Is Part Of: Leukemia & lymphoma. Volume 63:Issue 11(2022)
• Page Start: 2536
• Page End: 2544
• Publication Date: 2022-09-19
• Subjects: Clonal hematopoiesis -- cytopenia -- oligomonocytic-CMML -- splenomegaly -- double-mutated MPN -- MRD; Leukemia -- Periodicals; Lymphomas -- Periodicals; 616.99419
• DOI: 10.1080/10428194.2022.2087068
• Languages: English
• ISSNs: 1042-8194

Abstract

Abstract: The understanding of clonal hematopoiesis (CH) and its features is rapidly evolving in step with the spread of sequencing techniques. Indeed, CH detection is now an emerging aspect in clinical practice. The awareness of CH intersects with consolidated diagnostic paths, thus exposing 'grey zone' circumstances under the magnifying lens of clinicians. The interpretation of genomic data poses, in some cases, a true clinical challenge, sometimes further complicating the route to diagnosis. The line separating different entities is thin. The present work aims to review some of these challenging situations to help clinicians keep their balance along this tightrope.