A multicenter, randomized, open, controlled trial to evaluate the efficacy of Honglilai Vaginal Cream and Premarin Vaginal Cream for Genitourinary Syndrome of Menopause in different subgroups of Chinese postmenopausal women. (3rd October 2022)

• Record Type: Journal Article
• Authors: Yang, Mukun; Lin, Shouqing; Zheng, Shurong; Sun, Aijun; Bian, Meilu; Li, Shilan; Liu, Jianli; Hu, Lina; Hui, Ning; Zhong, Jing; Hou, Hongchun; Yue, Tianfu; Gao, Xiaoli; Bai, Wenpei
• Is Part Of: Gynecological endocrinology. Volume 38:Number 10(2022)
• Page Start: 861
• Page End: 867
• Publication Date: 2022-10-03
• Subjects: Genitourinary Syndrome of Menopause -- Vaginal Maturation Index -- Honglilai Vaginal Cream -- Premarin Vaginal Cream -- age; 绝经后泌尿生殖综合征 -- 阴道成熟指数 -- 红丽来阴道乳膏 -- 倍美力阴道乳膏 -- 年龄; Endocrine gynecology -- Periodicals; Generative organs, Female -- Diseases -- Periodicals; 618.1
• DOI: 10.1080/09513590.2022.2118710
• Languages: English
• ISSNs: 0951-3590

Abstract

Abstract: Aim: In a randomized, multicenter, open, controlled trial, we compared the effects of Honglilai Vaginal Cream and Premarin Vaginal Cream in different age subgroups and menopausal year subgroups (trial registration numbers: 02003L00493). Methods: Postmenopausal women with Genitourinary Syndrome of Menopause (GSM) were divided into Honglilai group ( n = 319) and Premarin group ( n = 116), while subgroups were divided according to their different characteristics of age and menopausal years. Honglilai Vaginal Cream (0.625 mg/g) or Premarin Vaginal Cream (0.625 mg/g) once daily for 3 weeks. Results: In the subgroup of participates >60 years, there were no significant differences of Vaginal Cell Maturation Index (VMI) between the two groups after treatment ( p = .171). In the subgroup of 50–59 years, the VMI of Honglilai group was significantly lower than Premarin group (Honglilai group: 74.37 ± 22.76; Premarin group: 80.06 ± 16.15; p = .02). There were no significant differences of Vaginal symptom scores between Honglilai group and Premarin group in every sub-group ( p > .05). Conclusions: Honglilai Vaginal Cream had comparable efficacy with Premarin Vaginal Cream in Chinese women older than 60 years.