Uveitis-Glaucoma-Hyphema Syndrome: Clinical Features and Differential Diagnosis. (18th August 2022)

• Record Type: Journal Article
• Authors: Accorinti, Massimo; Saturno, Maria Carmela; Paroli, Maria Pia; De Geronimo, Daniele; Gilardi, Marta
• Is Part Of: Ocular immunology and inflammation. Volume 30:Number 6(2022)
• Page Start: 1408
• Page End: 1413
• Publication Date: 2022-08-18
• Subjects: Uveitis -- glaucoma -- hyphema -- hypertensive uveitis -- differential diagnosis -- anterior uveitis; Eye -- Diseases -- Immunological aspects -- Periodicals; Eye -- Inflammation -- Periodicals; 617.7
• DOI: 10.1080/09273948.2021.1881563
• Languages: English
• ISSNs: 0927-3948

Abstract

ABSTRACT: Purpose: to study the clinical features of uveitis-glaucoma-hyphema (UGH) syndrome, particularly those useful for a differential diagnosis from unilateral hypertensive acute anterior uveitis. Methods: A retrospective chart review was conducted on the clinical features of 9 patients with UGH syndrome. These features were then compared with those detected in 50 patients with unilateral hypertensive acute anterior uveitis. Results: Fine and pigmented keratic precipitates ( p = .0002 and p = .00004, respectively), iris atrophy ( p = .0122), hyphema and vitreous opacities > 2+ ( p = .0003), and cystoid macular edema ( p = .009) were statistically associated with UGH syndrome. These clinical signs show a high specificity, ranging from 58 to 100%; the presence of pigmented keratic precipitates in the setting of a unilateral acute hypertensive anterior uveitis has a sensitivity and specificity of 89% and 84%, respectively. Conclusion: In patients operated on for cataract, UGH syndrome can be differentiated from unilateral hypertensive acute anterior uveitis considering specific clinical signs.