A convenient synthesis, biological activity and X-ray crystallography of novel α-aminophosphonate derivatives. (11th November 2022)

• Record Type: Journal Article
• Authors: Bahadi, Rania; Boughoula, Rahma; Berredjem, Malika; Bachari, Khaldoun; Bouzina, Abdeslem; Bouacida, Sofiane; Sbartai, Hana; Benalliouche, Fouzia; Redjemia, Rayenne
• Is Part Of: Phosphorus, sulfur, and silicon and the related elements. Volume 197:Number 11(2022)
• Page Start: 1150
• Page End: 1156
• Publication Date: 2022-11-11
• Subjects: Aminophosphonates -- ultrasound irradiation -- X-ray study -- antifungal activity -- antioxidant activity; Sulfur compounds -- Periodicals; Organosulfur compounds -- Periodicals; Phosphorus compounds -- Periodicals; Organophosphorus compounds -- Periodicals; Silicon compounds -- Periodicals; Organosilicon compounds -- Periodicals; 546
• DOI: 10.1080/10426507.2022.2064859
• Languages: English
• ISSNs: 1042-6507

Abstract

Abstract: A new series of novel α-aminophosphonate derivatives have been synthesized by new rapid and convenient approach, based on the stepwise one pot reaction of 2-hydroxyaniline, aromatic aldehydes and triethyl phosphite. The structures of all compounds have been identified by appropriate spectroscopic methods such as FTIR, 1 H, 13 C, 31 P NMR and ESI-MS. The crystal structure of diethyl-(2-fluorophenyl)-(2-hydroxy-4-methylphenyl)amino phosphonate has been determined, it crystallizes in the P -1 space group. In vitro antifungal activity of the synthesized compounds were tested against wheat fusarium ( Fusarium oxysporum ) and compared with standard antifungal drug Chlorpyriphos EC to explore their potential antifungal activity. We also measured the antioxidant activity of these molecules, compared with vitamin C as standard antioxidant. Graphical Abstract: UF0001