A review: Systematic research approach on toxicity model of liver and kidney in laboratory animals. Issue 5 (2nd August 2022)

• Record Type: Journal Article
• Authors: Abbasnezhad, Abbasali; Salami, Fatemeh; Mohebbati, Reza
• Is Part Of: Animal models and experimental medicine. Volume 5:Issue 5(2022)
• Page Start: 436
• Page End: 444
• Publication Date: 2022-08-02
• Subjects: animal -- drug toxicity -- drug‐induced abnormality -- liver dysfunction -- renal injury; Laboratory animals -- Periodicals; Diseases -- Animal models -- Periodicals; Animal models in research -- Periodicals; Veterinary medicine -- Periodicals; Laboratory Animal Science; Disease Models, Animal; Animals, Laboratory; Animal Welfare; Veterinary Medicine; Animal models in research; Diseases -- Animal models; Laboratory animals; Veterinary medicine; Periodicals; Fulltext; Internet Resources; Periodicals; Periodicals; 616.0273
• DOI: 10.1002/ame2.12230
• Languages: English
• ISSNs: 2576-2095

Abstract

Abstract: Therapeutic experiments are commonly performed on laboratory animals to investigate the possible mechanism(s) of action of toxic agents as well as drugs or substances under consideration. The use of toxins in laboratory animal models, including rats, is intended to cause toxicity. This study aimed to investigate different models of hepatotoxicity and nephrotoxicity in laboratory animals to help researchers advance their research goals. The current narrative review used databases such as Medline, Web of Science, Scopus, and Embase and appropriate keywords until June 2021. Nephrotoxicity and hepatotoxicity models derived from some toxic agents such as cisplatin, acetaminophen, doxorubicin, some anticancer drugs, and other materials through various signaling pathways are investigated. To understand the models of renal or hepatotoxicity in laboratory animals, we have provided a list of toxic agents and their toxicity procedures in this review. Abstract : To create models of toxicity, substances or drugs can be used that make this possible for the researcher. In this review article, we tried to provide a list of materials and drugs that cause hepatotoxicity models in laboratory animals, along with the relative protocol for creating that model for researchers so that they can make appropriate choices depending on the situation.