Tenofovir-Associated Fanconi Syndrome in Patients with Chronic Hepatitis B Monoinfection. Issue 7 (October 2013)

• Record Type: Journal Article
• Authors: Gracey, David M; Snelling, Paul; McKenzie, Paul; Strasser, Simone I
• Is Part Of: Antiviral therapy. Volume 18:Issue 7(2013)
• Page Start: 945
• Page End: 948
• Publication Date: 2013-10
• Subjects: Antiviral agents -- Periodicals; Antiviral Agents -- therapeutic use; Virus Diseases -- therapy; Viruses -- drug effects; Antiviral agents; Periodical; Electronic journals; Periodicals; 616.9106
• DOI: 10.3851/IMP2649
• Languages: English
• ISSNs: 1359-6535

Abstract

Tenofovir disoproxil fumarate (TDF) is increasingly used in patients with chronic hepatitis B (CHB) infection. Although associated with renal toxicity in HIV-infected patients, renal dysfunction has been reported rarely in the monoinfected CHB population. To date, TDF-associated Fanconi syndrome has not been reported. Here, we present two cases of TDF-associated Fanconi syndrome with rapid resolution after its cessation. We then discuss risk factors for TDF nephrotoxicity and its implications for screening for renal disease in those patients with CHB monoinfection on TDF, and the use of TDF in at-risk populations.