Article Commentary: Drug–Drug Interactions in HIV Therapy: Is it All Clear?. Issue 5 (July 2013)

• Record Type: Journal Article
• Authors: Burger, David; Back, David
• Is Part Of: Antiviral therapy. Volume 18:Issue 5(2013)
• Page Start: 649
• Page End: 650
• Publication Date: 2013-07
• Subjects: Antiviral agents -- Periodicals; Antiviral Agents -- therapeutic use; Virus Diseases -- therapy; Viruses -- drug effects; Antiviral agents; Periodical; Electronic journals; Periodicals; 616.9106
• DOI: 10.3851/IMP2688
• Languages: English
• ISSNs: 1359-6535

Abstract

Drug–drug interactions in HIV therapy have been known to the clinic from earliest days of HIV treatment. Hundreds of well-designed pharmacokinetic studies have been performed in either HIV-infected patients or, mostly, in healthy volunteers. Case reports generally are graded lower in terms of evidence-based medicine but sometimes provide valuable information. In this issue of Antiviral Therapy a case of virological failure on an atazanavir-containing regimen was explained by an interaction with charcoal that was used as self-medication for diarrhoea. Clinicians are invited to continue submitting well-documented case reports to increase knowledge on drug–drug interactions in HIV therapy even further.