An Association between Adiposity and Serum Levels of Macrophage Inflammatory Protein-1α and Soluble Cd14 in HIV-Infected Adults: Results from a Cross-Sectional Study. Issue 5 (July 2013)

• Record Type: Journal Article
• Authors: Koethe, John R; Bian, Aihua; Shintani, Ayumi K; Wester, C William; Erdem, Husamettin; Hulgan, Todd
• Is Part Of: Antiviral therapy. Volume 18:Issue 5(2013)
• Page Start: 729
• Page End: 733
• Publication Date: 2013-07
• Subjects: Antiviral agents -- Periodicals; Antiviral Agents -- therapeutic use; Virus Diseases -- therapy; Viruses -- drug effects; Antiviral agents; Periodical; Electronic journals; Periodicals; 616.9106
• DOI: 10.3851/IMP2645
• Languages: English
• ISSNs: 1359-6535

Abstract

Background: Greater adipose tissue is associated with increased circulating high-sensitivity C-reactive protein (hsCRP) levels in HIV-infected adults on antiretroviral therapy (ART), but the relationship between adiposity and other inflammation biomarkers is not well-characterized. Methods: We measured total and regional adipose tissue deposits using dual energy X-ray absorptiometry (DXA) and serum levels of interleukin-6 (IL-6), tumour necrosis factor-α (TNF-α) receptor 1 and 2, macrophage inflammatory protein-1α (MIP-1α), macrophage chemotactic protein-1 (MCP-1), soluble CD14 and hsCRP in a cohort of adults on long-term ART. Regression models were adjusted for age, sex, CD4 + T-cell count, smoking status, protease-inhibitor-use and daily use of either non-steroidal anti-inflammatory drugs or aspirin. Results: The majority (77%) of the 85 study participants were male, median CD4 + T-cell count was 500 cells/ ml (IQR 315-734) and median BMI was 25.1 kg/m 2 (IQR 22.7-28.1). DXA measurements of total fat mass were positively associated with serum hsCRP (β =1.82, P <0.01) and MIP-1α (β =1.36, P <0.01), but negatively associated with soluble CD14 (β =0.90, P <0.01). Results were similar for trunk fat, limb fat and serum leptin level. The positive relationship between DXA measurements and TNF-α receptor 1 approached significance ( P≤0.07 for all). There was no consistent relationship between adiposity and serum IL-6, TNF-α receptor 2 or MCP-1 levels. Conclusions: Total and regional adiposity was associated with serum hsCRP, but not other inflammatory cytokines shown to predict morbidity and mortality in treated HIV. Greater adiposity is associated with higher MIP-1α and lower soluble CD14 levels, possibly reflecting an important role for cells of the monocyte/macrophage lineage.