Efavirenz Intoxication Due to a New Cyp2B6 Constellation. Issue 5 (July 2013)

• Record Type: Journal Article
• Authors: Anagnostopoulos, Alexia; Rotger, Margalida; Aouri, Manel; Kuster, Stefan P; Telenti, Amalio; Décosterd, Laurent A; Günthard, Huldrych F
• Is Part Of: Antiviral therapy. Volume 18:Issue 5(2013)
• Page Start: 739
• Page End: 743
• Publication Date: 2013-07
• Subjects: Antiviral agents -- Periodicals; Antiviral Agents -- therapeutic use; Virus Diseases -- therapy; Viruses -- drug effects; Antiviral agents; Periodical; Electronic journals; Periodicals; 616.9106
• DOI: 10.3851/IMP2571
• Languages: English
• ISSNs: 1359-6535

Abstract

Here, we describe severe neuropsychiatric symptoms in an HIV-positive Asian man with extremely high efavirenz plasma levels while receiving standard treatment with efavirenz/tenofovir/emtricitabine fixed-dose regimen. Genetic examination revealed compound homozygosity for loss-of-function alleles of CYP2B6, including coding for a rare truncated protein. Neuropsychiatric symptoms resolved completely after efavirenz discontinuation.