Exploring potential serum levels of Homocysteine, interleukin‐1 beta, and apolipoprotein B 48 as new biomarkers for patients with ischemic stroke. Issue 10 (7th September 2021)

• Record Type: Journal Article
• Authors: Shademan, Behrouz; Nourazarian, Alireza; Laghousi, Delara; Karamad, Vahidreza; Nikanfar, Masoud
• Is Part Of: Journal of clinical laboratory analysis. Volume 35:Issue 10(2021)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2021-09-07
• Subjects: apolipoprotein B 48 -- Body Mass Index -- Homocysteine -- interleukin‐1β -- ischemic Stroke; Diagnosis, Laboratory -- Periodicals; Medical laboratory technology -- Periodicals; 616
• DOI: 10.1002/jcla.23996
• Languages: English
• ISSNs: 0887-8013

Abstract

Abstract: Background: Stroke is the second leading cause of death worldwide with heterogeneous characteristics. The subtypes of stroke are due to different pathophysiological regulations and causes. This study aimed to investigate the correlation of serum levels of apolipoprotein B 48, interleukin‐1β and Homocysteine with BMI in patients with ischemic stroke (IS). Methods: Over one hundred controls (120) and an equal number of IS patients, including 31 women and 89 men, were recruited to participate in the case‐control study conducted at Imam Reza Hospital (Tabriz, Iran) from February 2019 to March 2020. We measured serum levels of apolipoprotein B 48, interleukin‐1β, and Homocysteine. Receiver operating characteristic analysis (ROC) was performed to evaluate the diagnostic value of these indices in patients and control groups. Results: The mean serum levels of apolipoprotein B 48, interleukin‐1β, and Homocysteine, were significantly increased in the experimental group compared to the control group with a p ‐value of 0.001. The ROC curve analysis showed that the area under the curve for apo B48, IL −1β, hs‐CRP, and Homocysteine serum levels were 0.94, 0.98, 0.99, and 1, respectively. Conclusions: The results of our current study show that the determination of serum levels of apolipoprotein B 48, interleukin‐1β, and Homocysteine can potentially be used to monitor and diagnose IS patients. However, there was no statistically significant correlation between serum levels of apolipoprotein B 48, interleukin 1β and Homocysteine and BMI in the patient group. However, there was a statistically significant inverse correlation between serum levels of high‐sensitivity C‐reactive protein (hs‐CRP) and BMI in the patient group. Abstract : Background Stroke is ranked as the second most prevalent cause of mortality worldwide with heterogeneous characteristics. The subtypes of stroke result from distinct pathophysiological regulations and reasons. The objective of this study was to evaluate the correlation of serum levels of apolipoprotein B 48, interleukin‐1β, and homocysteine with BMI in ischemic stroke (IS) patients.Methods Over one hundred controls (120) and an equal number of IS patients, including 31 women and 89 men, were recruited to participate in the case‐control investigation conducted at Imam Reza Hospital (Tabriz, Iran) from February 2019 to March 2020. We measured serum levels of apolipoprotein B 48, interleukin‐1β, and homocysteine. The analysis of receiver operating characteristics (ROC) was performed to evaluate the incremental diagnostic value of these indices in patients and control groups.Results Mean serum levels of apolipoprotein B 48, interleukin‐1β, and homocysteine were remarkably elevated in the experimental group compared with the control group with a p‐value of 0.001. The analysis of ROC unraveled the diagnostic value of apolipoprotein B‐48, interleukin‐1β, and homocysteine for IS demonstrated by a region under the ROC curve of less than 0.98, a p‐value of less than 0.001, and significant specificity and sensitivity.Conclusions Findings from our current study revealed that assessment of serum levels of apolipoprotein B 48, interleukin‐1β, and homocysteine could be potentially utilized to monitor and diagnose IS patients. However, there was no statistically significant correlation between serum levels of apolipoprotein B 48, interleukin 1β, and homocysteine and BMI in the patient group. However, there was a statistically significant inverse correlation between serum levels of high‐sensitivity C‐reactive protein (hs‐CRP) and BMI in the patient group.